Atralin: a new prescription retinol with less irritation risk
Just started reading about Atralin, a tretinoin (like Retin-A) that contains moisturizers to lower the chance of irritation.
What is Atralin?
ATRALIN® (tretinoin) Gel, 0.05%, is for topical use prescribed to treat acne.
I’ll have to ask my derm about it next time I’m in – this looks promising.
My Atralin Experience
So update, I tried it and LOVE it. There is a nice buffer built-in but it absorbs into skin without residue or gritty feel. It feels so good on the skin, I have to be careful not to over-apply.
Check out the texture:

Atralin Ingredients
According to the prescription literature, the other components of this formulation are:
benzyl alcohol – an organic alcohol from fruit, a preservative
butylparaben
butylated hydroxytoluene – preservative
carbomer homopolymer Type C – thickener in gel formulas that holds moisture
ethylparaben
fish collagen hydrolyzates – fish collagen, broken into absorbable pieces, used to slow skin aging and for wound healing. It also improves skin hydration and elasticity.
glycerin
isobutylparaben
methylparaben
octoxynol 9
phenoxyethanol
propylparaben
purified water
sodium hyaluronate
trolamine
References
Sanchez A, Blanco M, Correa B, Perez-Martin RI, Sotelo CG. Effect of Fish Collagen Hydrolysates on Type I Collagen mRNA Levels of Human Dermal Fibroblast Culture. Mar Drugs. 2018 Apr 26;16(5):144. doi: 10.3390/md16050144. PMID: 29701725; PMCID: PMC5983275.